The average ratio of DHA/EPA in the various long-term population studies which have investigated fish intake in relation to a reduced mortality from cardiovascular disease, has ranged from approximately 2/1 to 3/1. For individuals with coronary heart disease the American Heart Association has recommended a combined intake of DHA+EPA of 900 mg/day without specifying the proportion of the mixture which should be represented by each of the two components. In 1999, a workshop convened at the National Institutes of Health in Bethesda, Maryland recommended a combined DHA/EPA intake of 650 mg/day for normal healthy adults with a provision that at least one third of the mixture should be represented by either DHA or EPA. In other words, the DHA/EPA ratio should fall between 2/1 and 1/2. No controlled studies to date have directly compared DHA/EPA mixtures with DHA alone or EPA alone.